List of publications:
Magnetosome heating mechanisms by applying an oscillating field :
Heat Production by Bacterial Magnetosomes Exposed to an Oscillating Magnetic Field, E. Alphandéry, S. Faure, L. Reason, E. Duguet, P.A. Howse, and D.A. Bazylinski, Journal of Physical Chemistry C, Vol. 115, p. 18-22 (2011).
Link 1: http://pubs.acs.org/doi/abs/10.1021/jp104580t
Link 2: https://hal-univ-diderot.archives-ouvertes.fr/hal-00559506/document
Doping magnetosomes with cobalt to improve their heating properties :
Chains of Cobalt Doped Magnetosomes Extracted from AMB-1 Magnetotactic Bacteria for Application in AMF Hyperthermia, E. Alphandery, Carvallo C., Menguy N., Chebbi I., Journal of Physical Chemistry C, Vol. 115, p. 11920-11924 (2011).
Link 1: http://pubs.acs.org/doi/abs/10.1021/jp201274g
Link 2: https://hal-univ-diderot.archives-ouvertes.fr/hal-00643500/document
Mechanism of stimulation of bacterial production by addition of chelating additive :
The effect of iron-chelating agents on Magnetospirillum magneticum strain AMB-1: stimulated growth and magnetosome production and improved magnetosome heating properties, E. Alphandéry, M. Amor, F. Guyot & I. Chebbi, Applied Microbiology and Biotechnology, Vol. 96, 663-670 (2012).
Link 1: https://link.springer.com/article/10.1007%2Fs00253-012-4199-5
Link 2: https://www.archives-ouvertes.fr/IMPMC/hal-01547086v1
Treatment of breast cancer by magnetic hyperthermia using magnetosomes :
Preparation of chains of magnetosomes, Magnetospirillum magneticum strain AMB-1 magnetotactic bacteria, Yielding efficient treatment of tumors using magnetic hyperthermia, E. Alphandéry, Guyot F., I. Chebbi, International Journal of Pharmaceutics, Vol. 434, p. 444-452 (2012).
Link 1: http://www.sciencedirect.com/science/article/pii/S0378517312006126?via%3Dihub
Link 2: http://hal.upmc.fr/hal-01547081
Chains of Magnetosomes Extracted from AMB-1 Magnetotactic Bacteria for Application in Alternative Magnetic Field Cancer Therapy, E. Alphandéry, S. Faure, O. Seksek, F. Guyot, and I. Chebbi, ACSNano, Vol. 5, p. 6279-6296 (2011).
Link 1: http://pubs.acs.org/doi/abs/10.1021/nn201290k
Link 2: http://pubs.acs.org/doi/abs/10.1021/nn201290k
Use of magnetosomes as a magnetic detection probe :
Abstract: A new technology for multiparametric detection, E. Alphandérya, L. Lijeour, Y. Lalatonne, L. Motte, Sensors and Actuators B: Chemical, Vol. 147, p. 786-790 (2010).
Link 1: http://www.sciencedirect.com/science/article/pii/S092540051000328X
Link 2: https://hal.archives-ouvertes.fr/hal-00704892/document
Review on the development of different nano-drugs :
Cancer Therapy Using Nanoformed Substances: Scientific, Regulatory and Financial Aspects, E. Alphandéry, P. Grand-Dewyse, R. Le Fevre, C. Mandawala, M. Durand-Dubief, Expert Review of Anticancer Therapy, Vol 15, P. 1233 -1255 (2015).
Link 1: http://www.tandfonline.com/doi/abs/10.1586/14737140.2015.1086647?journalCode=iery20
Link 2: http://hal.upmc.fr/hal-01547085
Preparation and properties of coated pyrogen-free magnetosome minerals :
Biocompatible and stable magnetosome minerals coated with poly-L-lysine, citric acid, oleic acid, and carboxy-methyl-dextran for application in the magnetic hyperthermia treatment of tumors, C. Mandawala, I. Chebbi, M. Durand-Dubief, R Le Fevre, Y. Hamdous, F. Guyot, E. Alphandery, Journals of Materials Chemistry B, Vol. 5, p. 7644-7660 (2017).
Link 1: http://pubs.rsc.org/en/content/articlelanding/2017/tb/c6tb03248f#!divAbstract
Link 2: https://www.archives-ouvertes.fr/IMPMC/hal-01586778v1
Biocompatible coated magnetosome minerals with various organism and cellular interaction properties induce cytotoxicity towards RG-2 and GL-261 glioma cells in the presence of an alternating magnetic field, Y. Hamdous, I. Chebbi, Ch. Mandawala, R. Le Fevre, F Guyot, O. Seksek, and E. Alphandéry, Journal of Nanobiotechnology, V. 15:74 (2017).
Link: https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-017-0293-2
Treatment of intracranial U87-Luc glioblastomas :
Chains of magnetosomes with controlled endotoxin release and partial tumor induce full destruction of intracranial U87-Luc glioma in mice under the application of an alternating magnetic field, E. Alphandéry, A. Idbaih, C. Adam, J-Y. Delattre, C. Schmitt, F. Guyot, I. Chebbi, Journal of Controlled Release, V. 262, P. 259-272 (2017).
Link 1: http://www.sciencedirect.com/science/article/pii/S0168365917307290?via%3Dihub
Link 2: https://hal-mnhn.archives-ouvertes.fr/hal-01565231v1
The development of non-pyrogenic magnesium oxide coated with poly-l-lysine in U87-Luc glioblastoma in 100% of treated mice using magnetic hyperthermia, E. Alphandéry, A. Idbaih, C. Adam, J-Y. Delattre, C. Schmitt, F. Guyot, I. Chebbi, Biomaterials, V. 141, P. 210-222 (2017).
Link 1: https://www.ncbi.nlm.nih.gov/pubmed/28689117
Link 2: https://hal-mnhn.archives-ouvertes.fr/hal-01545933v1
Treatment of subcutaneous glioblastoma GL-261 :
Enhanced antitumor efficacy of biocompatible magnetosomes for the magnetic hyperthermia treatment of glioblastoma, Raphael Le Fevre, Mickael Durand-Dubief, Imene Chebbi, Chalani Mandawala, Lagroix France, Jean-Pierre Valet, Ahmed Idbaih, Adam Clovis, Jean-Yves Delattre, Charlotte Schmitt , Caroline Maake, François Guyot, Edouard Alphandéry, Theranostics, V. 7, P. 4618-4631 (2017).
Link 1: http://www.thno.org/v07p4618.htm
Link 2: http://www.thno.org/v07p4618.pdf
Development of a nanometric fluorescent probe for temperature detection :
A Nanoprobe Synthesized by Magnetotactic Bacteria, Detecting Fluorescence Variations under Dissociation of Rhodamine B from Magnetosomes Following Temperature, pH Changes, or the Application of Radiations. Edouard Alphandery, Darine Abi-Haidar, Olivier Seksek, Maxime Thoreau, Alain Trautmann, Nadege Bercovici, Florence Gazeau, Francois Guyot, Imene Chebbi. ACS applied materials and interfaces. DOI: 10.1021 / acsami.7b09720 (2017)
Link 1: http://pubs.acs.org/doi/abs/10.1021/acsami.7b09720
Link 2: http://hal.archives-ouvertes.fr/hal-01123077
Review on medical use of Magnetosomes :
Use of bacterial magnetosomes in the magnetic hyperthermia treatment of tumors: A review. Edouard Alphandéry, Imène Chebbi, Francois Guyot, Mickael Durand-Dubief. International Journal of Hyperthermia, V. 29, P. 801-809 (2013).
Link 1: http://www.tandfonline.com/doi/pdf/10.3109/02656736.2013.821527
Application of magnetosomes synthesized by magnetotactic bacteria in medicine. Edouard Alphandéry. Frontiers in Bioengineering and biotechnology. V. 2, Article 5 (2014).
Link: https://journal.frontiersin.org/article/10.3389/fbioe.2014.00005/pdf
Review on therapeutic therapies used for the treatment of breast Cancer :
Perspective of breast cancer thermotherapies. Edouard Alphandéry. Journal of Cancer, V. 5, 472 (2014).
Link 1: www.jcancer.org/v05p0472.htm
Link 2: www.jcancer.org/v05p0472.pdf
Iron isotopes in magnetosomes :
Mass-dependent and -independent signature of Fe isotopes in magnetotactic bacteria. Matthieu Amor, Vincent Busigny, Pascale Louvat, Alexandre Gélabert, Pierre Cartigny, Mickael Durand-Dubief, Georges Ona-Nguema, Edouard Alphandéry, Imène Chebbi, François Guyot. Science. Flight. 352, P.705-708 (2016).
Link: http://science.sciencemag.org/content/352/6286/705
Chemical signature of magnetotactic bacteria. Matthieu Amor, Vincent Busigny, Mickael Durand-Dubief, Georges Ona-Nguema, Alexandre Gélabert, Edouard Alphandéry, Nicolas Menguy, Marc Benedeti, Imène Chebbi, François Guyot. Proceedings of the National Academy of Science. V. 112, p. 1699-1703 (2015).
Link: http://europepmc.org/articles/PMC4330721
Review on therapies used for the treatment of glioblastoma :
Glioblastoma Treatments: An Account of Recent Industrial Developments. Edouard Alphandéry. Frontiers in Pharmacology. V 13; 9:879 (2018).
Link 1 : https://www.ncbi.nlm.nih.gov/pubmed/30271342
Link 2 : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147115/
Use of fluorescent magnetosomes for drug release :
Fluorescent magnetosomes for controlled and repetitive drug release under the application of an alternating magnetic field under conditions of limited temperature increase (<2.5 °C). Edouard Alphandéry, Darine Abi Haidar, Olivier Seksek, François Guyot, Imène Chebbi. Nanoscale. Vol 14; 10(23): 10918-10933 (2018).
Link : https://www.ncbi.nlm.nih.gov/pubmed/29850738
Iron isotope study for the biomineralization of magnetite in bacteria :
Iron uptake and magnetite biomineralization in the magnetotactic bacterium Magnetospirillum magneticum strain AMB-1: An iron isotope study. Matthieu Amora, Vincent Busigny, Pascale Louvat, Mickaël Tharaud, Alexandre Gélabert, Pierre Cartigny, Julie Carlut, Aude Isambert, Mickaël Durand-Dubief, Georges Ona-Nguema, Edouard Alphandéry, Imène Chebbi, François Guyot. Geochimica et Cosmochimica Acta Volume 232, Pages 225-243 (2018).
Link : https://doi.org/10.1016/j.gca.2018.04.020
Mechanisms of magnetosomes chains orientation in magnetotactic bacteria :
Magnetic-field induced rotation of magnetosome chains in silicified magnetotactic bacteria. Marine Blondeau, Yohan Guyodo, François Guyot, Christophe Gatel, Nicolas Menguy, Imène Chebbi, Bernard Haye, Mickaël Durand-Dubief, Edouard Alphandery, Roberta Brayner, Thibaud Coradin. Scientific Reports. Vol 16;8(1):7699 (2018).
Link 1 : https://www.ncbi.nlm.nih.gov/pubmed/29769616
Link 2 : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955880/
Treatment of intracranial U87-Luc glioblastomas :
Biodegraded magnetosomes with reduced size and heating power maintain a persistent activity against intracranial U87‑Luc mouse GBM tumors. . V 17:126 (2019).
Lien 1 : https://pubmed.ncbi.nlm.nih.gov/31870376/
Lien 2 : https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-019-0555-2
Review on iron oxide nanoparticles as imaging tool :
Iron oxide nanoparticles as multimodal imaging tools.
Lien : https://doi.org/10.1039/C9RA08612A
Review on biodistribution and targeting properties of iron oxide nanoparticles for the treatment of cancer and iron anemia :
Biodistribution and targeting properties of iron oxide nanoparticles for treatments of cancer and iron anemia disease.
Lien : https://doi.org/10.1080/17435390.2019.1572809
Review on nanomedecine regulations :
A discussion on existing nanomedicine regulation: Progress and pitfalls. Applied Materials Today. Vol 17 193–205 (2019).
Lien : https://doi.org/10.1016/j.apmt.2019.07.005
Review on the therapeutic use of iron oxide nanoparticles :
Iron oxide nanoparticles for therapeutic applications. Drug Discovery Today. Volume 25, Issue 1, Pages 141-149 (2020).
Lien : https://doi.org/10.1016/j.drudis.2019.09.020
Review on the therapeutic use of nanotechnology for the treatment and the diagnostic of coronavirus :
The Potential of Various Nanotechnologies for Coronavirus Diagnosis/Treatment Highlighted through a Literature Analysis. Bioconjugate Chem. Vol 31, 1873−1882 (2020).
Lien : https://doi.org/10.1021/acs.bioconjchem.0c00287
Review on the therapeutic use of biomineralized iron oxide nanoparticles for the treatment of cancer :
Bio-synthesized iron oxide nanoparticles for cancer treatment. International Journal of Pharmaceutics. Vol 586 119472 (2020).
Lien : https://doi.org/10.1016/j.ijpharm.2020.119472
Review on the therapeutic use of metallic nanoparticles in oncology :
Natural Metallic Nanoparticles for Application in Nano-Oncology. Edouard Alphandéry. Int J Mol Sci. Vol 21(12): 4412 (2020).
Lien : https://doi.org/10.3390/ijms21124412
Review on the therapeutic use of magnetotactic bacteria and magnetosomes for cancer treatment :
Applications of magnetotactic bacteria and magnetosome for cancer treatment: A review emphasizing on practical and mechanistic aspects. Edouard Alphandéry. Drug Discovery Today. Vol 25, NO 8 (2020).
Lien : https://doi.org/10.1016/j.drudis.2020.06.010
Review on therapeutic use of nanotechnology for the treatment of glioblastoma :
Nano-Therapies for Glioblastoma Treatment. Edouard Alphandéry. Cancers (Basel). Vol 12(1): 242 (2020).
Lien : https://doi.org/10.3390/cancers12010242
Production of magnetosomes by the bacterial strain MSR-1 in a minimal growth media :
A Method for Producing Highly Pure Magnetosomes in Large Quantity for Medical Applications Using Magnetospirillum gryphiswaldense MSR-1 Magnetotactic Bacteria Amplified in Minimal Growth Media. Clément Berny, Raphael Le Fèvre, François Guyot, Karine Blondeau, Christine Guizonne, Emilie Rousseau, Nicolas Bayan and Edouard Alphandéry. Front Bioeng Biotechnol. Vol 8: 16 (2020).